Semaglutide reconstitution calculator
Semaglutide reconstitution calculator. Enter vial size and bacteriostatic water to get concentration and the insulin syringe units for any amount.
| Amount | Units (U-100) | mL |
|---|---|---|
| 50 mcg | 1 | 0.01 |
| 100 mcg | 2 | 0.02 |
| 250 mcg | 5 | 0.05 |
| 500 mcg | 10 | 0.1 |
| 1 mg | 20 | 0.2 |
| 2 mg | 40 | 0.4 |
| 2.5 mg | 50 | 0.5 |
| 5 mg | 100 | 1 |
How the math works
Concentration is the peptide in the vial divided by the water you add. A 10 mg vial with 2 mL of bacteriostatic water holds 5 mg (5,000 mcg) per mL. On a U-100 insulin syringe, 1 mL is 100 units, so each unit carries 50 mcg. To draw 250 mcg you would pull 5 units.
The amount field is blank on purpose. This site does not suggest amounts. The Semaglutide page lists what published studies used.
Doses used in published research
What investigators actually administered, as reported in the cited study. This is a record of the literature, not a recommendation.
| Study | Population | Regimen |
|---|---|---|
| STEP 1, Wilding et al., NEJM 2021 | 1,961 adults with obesity or overweight plus a weight-related condition, without diabetes | 2.4 mg subcutaneous once weekly plus lifestyle intervention, 68 weeks |
| SELECT, Lincoff et al., NEJM 2023 | 17,604 adults with established cardiovascular disease and overweight or obesity, without diabetes | 2.4 mg subcutaneous once weekly vs placebo |
| Wegovy US prescribing information (label) | Adults in chronic weight management | Label escalation 0.25, 0.5, 1 and 1.7 mg weekly, four weeks each, to a 2.4 mg weekly maintenance dose |
New to this? Read Peptides 101 and the syringe units chart.
Common questions
How much bacteriostatic water should I add to a Semaglutide vial?
There is no single correct volume. More water makes each unit carry less peptide, which makes small amounts easier to measure; less water keeps volumes small. Most people pick a volume that puts their amount between 5 and 50 units on a U-100 syringe.
What does U-100 mean?
U-100 insulin syringes are marked in units where 100 units equals 1 mL. So 10 units is 0.1 mL regardless of what is in the syringe. Peptide calculators use this scale because insulin syringes are what is widely available in Philippine pharmacies.
Does the calculator work for mg and mcg?
Yes. 1 mg equals 1,000 mcg. Switch the unit next to the amount field and the result updates.
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